Scientists are a step towards the creation of an anti-aging, after discovering a key enzyme that blocks anti-aging, our cells from decaying.
It 'has long been known that reducing calorie intake can significantly slow down the aging process and improve health in adult life.
Now researchers at the University of Wisconsin-Madison have identified a key enzyme called SIRT3, which causes this dramatic effect in the molecules of the cells.
Lead scientist Professor Tomas Proll said: 'We are getting closer and closer to a good understanding of how caloric restriction.
'This study is the first direct evidence of a mechanism for anti-aging effects that we observe in caloric restriction.'
The discovery not only helps to explain the cascade of events that contributes to aging, but also provides a basis for designing drugs that could extend life span.
The team studied mice with an age-related hearing loss, which is linked to free radical damage to cells of the inner ear.
They focused on the mitochondria - structures within cells that produce energy and are sources of highly reactive forms of oxygen known as free radicals, which damage cells and promote aging effects.
The researchers found in conditions of low-calorie, increased levels of SIRT3 alter the metabolism and reduces free radicals produced by mitochondria.
Signs of free radical damage are the skin which is leathery or wrinkled and sagging, and stiffness.
infections, smoking, sunbathing, fried food, and stress may produce excess free radicals. However, green leafy vegetables and wholemeal bread contain antioxidants that can neutralize them.
Professor Proll said: 'This is the strongest and most direct link that caloric restriction works through the mitochondria.'
SIRT3 is one of seven enzymes of the Sirtuin family that seem to have a major impact on cell fate and physiology.
However, a new study published in the journal Cell, provides 'the first evidence that sirtuins have anti-aging in mammals.'
Understanding the molecular basis of how the work Sirtuin enzymes can lead to the development of drugs that activate the pathways of enzymes such as SIRT3 to slow down the aging process. More health information articles please click Here
It 'has long been known that reducing calorie intake can significantly slow down the aging process and improve health in adult life.
Now researchers at the University of Wisconsin-Madison have identified a key enzyme called SIRT3, which causes this dramatic effect in the molecules of the cells.
Lead scientist Professor Tomas Proll said: 'We are getting closer and closer to a good understanding of how caloric restriction.
'This study is the first direct evidence of a mechanism for anti-aging effects that we observe in caloric restriction.'
The discovery not only helps to explain the cascade of events that contributes to aging, but also provides a basis for designing drugs that could extend life span.
The team studied mice with an age-related hearing loss, which is linked to free radical damage to cells of the inner ear.
They focused on the mitochondria - structures within cells that produce energy and are sources of highly reactive forms of oxygen known as free radicals, which damage cells and promote aging effects.
The researchers found in conditions of low-calorie, increased levels of SIRT3 alter the metabolism and reduces free radicals produced by mitochondria.
Signs of free radical damage are the skin which is leathery or wrinkled and sagging, and stiffness.
infections, smoking, sunbathing, fried food, and stress may produce excess free radicals. However, green leafy vegetables and wholemeal bread contain antioxidants that can neutralize them.
Professor Proll said: 'This is the strongest and most direct link that caloric restriction works through the mitochondria.'
SIRT3 is one of seven enzymes of the Sirtuin family that seem to have a major impact on cell fate and physiology.
However, a new study published in the journal Cell, provides 'the first evidence that sirtuins have anti-aging in mammals.'
Understanding the molecular basis of how the work Sirtuin enzymes can lead to the development of drugs that activate the pathways of enzymes such as SIRT3 to slow down the aging process. More health information articles please click Here
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